Protein Name:
mRNA decay activator protein ZFP36
|
UniprotKB/SwissProt ID: D3ZHK9 (D3ZHK9)
Gene Name:
Zfp36l2
Organism: Rattus norvegicus (Rat)
Function: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, P-body. Nucleus. Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of D3ZHK9
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
204 |
LCRTFHTIGF C PYGPRCHFIH |
|
|
|
|
