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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Filamin-C

UniprotKB/SwissProt ID: D3ZHA0 (D3ZHA0)

Gene Name: Flnc

Organism: Rattus norvegicus (Rat)

Function: Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001589 Actinin_actin-bd_CS
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR044801 Filamin
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

The S-nitrosylation sites of D3ZHA0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1067 GVLPPDPSKV C AYGPGLKGGL   
2 1349 SPFRVGVTEG C DPTRVRAFGP   
3 1470 ARVPQTFTVD C SQAGRAPLQV   
4 1640 HALPTGDASK C LVTVSIGGHG   
5 1907 VEGPSKAEIT C KDNKDGTCTV   
6 1992 IRAPSGNEEP C LLKRLPNRHI   
7 2102 MEDGTCKVTY C PTEPGTYIIN   
8 2661 VGQKNSFTVD C SKAGTNMMMV   
9 2680 MVGVHGPKTP C EEVYVKHMGN   
10 473 SPFPVHVAEA C NPNACRASGR   
11 478 HVAEACNPNA C RASGRGLQPK