Protein Name:
Aldo-keto reductase family 1 member B15
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UniprotKB/SwissProt ID: C9JRZ8 (C9JRZ8)
Gene Name:
AKR1B15
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439) No oxidoreductase activity observed with the tested substrates
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of C9JRZ8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
187 |
KYKPVTNQVE C HPYLTQEKLI |
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