UniprotKB/SwissProt ID: B5TVM2 (B5TVM2)
Gene Name:
Ildr2
Organism: Mus musculus (Mouse)
Function: May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:23826244, PubMed:33863978). With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Cell junction, tight junction. Nucleus
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