Protein Name:
Multifunctional protein CAD
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UniprotKB/SwissProt ID: B2RQC6 (B2RQC6)
Gene Name:
Cad
Organism: Mus musculus (Mouse)
Function: Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of B2RQC6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
179 |
VFNAGGAPRI C ALDCGLKYNQ |
CCEEEECCCC E ECCCCCCCEE |
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| 2 |
192 |
DCGLKYNQIR C LCQLGAEVTV |
CCEEEECCCC E ECCCCCCCEE |
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| 3 |
2092 |
KHGRTVHSLA C LLTQYRVSLR |
CCEEEECCCC E ECCCCCCCEE |
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20925432
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| 4 |
280 |
RYGNRGHNQP C LLVGTGRCFL |
CCEEEECCCC E ECCCCCCCEE |
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20925432
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| 5 |
897 |
VRKLRQELGI C PAVKQIDTVA |
CCEEEECCCC E ECCCCCCCEE |
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20925432
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