UniprotKB/SwissProt ID: B1AYL1 (B1AYL1)
Gene Name:
Scn7a
Organism: Mus musculus (Mouse)
Function: Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:11027237, PubMed:11992118, PubMed:17408578, PubMed:27252474). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (PubMed:11027237, PubMed:17408578, PubMed:27252474). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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