Protein Name:
Sperm-egg fusion protein Juno
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UniprotKB/SwissProt ID: A6ND01 (A6ND01)
Gene Name:
IZUMO1R
Organism: Homo sapiens (Human)
Function: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:30517645). The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, microvillus membrane
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Graphical Visualization of S-nitrosylation Sites:
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