UniprotKB/SwissProt ID: A6H6A9 (A6H6A9)
Gene Name:
Rabgap1l
Organism: Mus musculus (Mouse)
Function: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome. Golgi apparatus
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