Protein Name:
CCR4-NOT transcription complex subunit 1
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UniprotKB/SwissProt ID: A5YKK6 (A5YKK6)
Gene Name:
CNOT1
Organism: Homo sapiens (Human)
Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, P-body. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of A5YKK6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1287 |
LNLKFEIEVL C KNLALDINEL |
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| 2 |
1457 |
NLTAGMAMIT C REPLLMSIST |
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| 3 |
1541 |
KHARQEGRRY C DPVVLTYQAE |
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| 4 |
1706 |
QDGRAYGSPW C NKQITRCLIE |
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| 5 |
1713 |
SPWCNKQITR C LIECRDEYKY |
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| 6 |
1932 |
AANPTMIRAK C YHNLDAFVRL |
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| 7 |
624 |
QACMTFLKRR C PSILGGLAPE |
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| 8 |
890 |
TIKREREVFN C MLRNLFEEYR |
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