UniprotKB/SwissProt ID: A4Q9F1 (A4Q9F1)
Gene Name:
Ttll8
Organism: Mus musculus (Mouse)
Function: Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins (PubMed:19524510, PubMed:28576883). Not involved in elongation step of the polyglycylation reaction (PubMed:19524510). Preferentially monoglycylates alpha-tubulin over beta-tubulin (PubMed:19524510). Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (PubMed:19524510, PubMed:23897886, PubMed:25180231). Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (PubMed:33414192). Monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1 (PubMed:19427864, PubMed:19524510)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme
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