Protein Name:
WD repeat-containing protein 91
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UniprotKB/SwissProt ID: A4D1P6 (A4D1P6)
Gene Name:
WDR91
Organism: Homo sapiens (Human)
Function: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane. Late endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of A4D1P6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
351 |
KELFSTTTSQ C AEKKPEASGP |
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