Protein Name:
tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial
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UniprotKB/SwissProt ID: A2AUU0 (A2AUU0)
Gene Name:
Mettl8
Organism: Mus musculus (Mouse)
Function: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (By similarity). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (By similarity). N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (By similarity). May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767). The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo (By similarity) Overexpression in lung progenitor cells stimulates smooth muscle-specific gene expression and suppresses adipogenic gene expression Stimulates adipogenesis Stimulates adipogenesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm. Nucleus. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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