UniprotKB/SwissProt ID: A2A259 (A2A259)
Gene Name:
Pkd2l1
Organism: Mus musculus (Mouse)
Function: Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:15548533, PubMed:28904867). Also forms functionnal heteromeric channels with PKD1, PKD1L1 and PKD1L3 (PubMed:15548533, PubMed:16891422, PubMed:18535624, PubMed:20538909, PubMed:21185261, PubMed:24336289, PubMed:34381056). Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:16891422, PubMed:16929298, PubMed:18535624, PubMed:19464260, PubMed:20406802, PubMed:20538909, PubMed:21098668, PubMed:21185261, PubMed:21625513, PubMed:22420714, PubMed:29567962). The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:18535624, PubMed:19464260, PubMed:20406802, PubMed:20538909, PubMed:22420714, PubMed:28904867, PubMed:29567962). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336288, PubMed:24336289). The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive (By similarity). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm) (PubMed:15548533). May play a role in the perception of carbonation taste (PubMed:19833970). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (PubMed:28553944)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, cilium membrane. Cell membrane. Cytoplasmic vesicle
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