Protein Name:
SH3 and PX domain-containing protein 2B
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UniprotKB/SwissProt ID: A1X283 (A1X283)
Gene Name:
SH3PXD2B
Organism: Homo sapiens (Human)
Function: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection, podosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of A1X283
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
664 |
PPQGEDQVDI C NLRSKLRPAK |
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| 2 |
783 |
RPLPEVRGPQ C EGHESRAAPT |
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