Protein Name:
Ubiquitin-like modifier-activating enzyme 6
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UniprotKB/SwissProt ID: A0AVT1 (A0AVT1)
Gene Name:
UBA6
Organism: Homo sapiens (Human)
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of A0AVT1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
156 |
TDLSFLDKYQ C VVLTEMKLPL |
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| 2 |
174 |
LPLQKKINDF C RSQCPPIKFI |
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| 3 |
197 |
DVHGIWSRLF C DFGDEFEVLD |
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| 4 |
347 |
EKYSRKPNVG C QQDSEELLKL |
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| 5 |
721 |
FNHKALQLLH C FPLDIRLKDG |
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| 6 |
96 |
KAVTIHDTEK C QAWDLGTNFF |
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