Protein Name:
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UniprotKB/SwissProt ID: A0A0G2K6P4 (A0A0G2K6P4)
Gene Name:
Hmgb1l1
Organism: Rattus norvegicus (Rat)
Function: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Chromosome. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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