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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Symplekin

UniprotKB/SwissProt ID: A0A0G2K1E5 (A0A0G2K1E5)

Gene Name: Sympk

Organism: Rattus norvegicus (Rat)

Function: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, tight junction. Cell membrane. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021850 Symplekin/Pta1
IPR032460 Symplekin/Pta1_N
IPR022075 Symplekin_C

The S-nitrosylation sites of A0A0G2K1E5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 578 RILRAEKAVA C SGAAQVRIKI   
2 848 SPELLLLVEN C PKGAETLVTR   
3 859 PKGAETLVTR C LHSLTDKVPP