Protein Name:
Active breakpoint cluster region-related protein
|
UniprotKB/SwissProt ID: A0A0G2JTR4 (A0A0G2JTR4)
Gene Name:
Abr
Organism: Rattus norvegicus (Rat)
Function: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, dendritic spine. Cell projection, axon. Synapse
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of A0A0G2JTR4
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
346 |
TSAGKHQQYD C KWYIPLADLV |
|
|
|
|
